Protective role of major histocompatibility complex class II Ebd transgene on collagen-induced arthritis.

摘要: Collagen-induced arthritis (CIA) is an animal model of autoimmune inflammatory polyarthritis that has features similar to rheumatoid (RA). Much like RA, susceptibility mouse CIA influenced by the major histocompatibility complex (MHC), H-2, and restricted H-2q H-2r haplotypes. Whereas role H-2A molecule in well established, little known about H-2E disease. In this study, we analyzed effect a transgenic E beta d on recombinant B10.RQB3, which expresses susceptible Aq genes Eak gene, but does not produce since Ebq nonfunctional. presence Ebd transgene, viable generated. B10.RQB3 were CIA, B10.RQB3-E d+ showed dramatic reduction incidence as decrease level anti-mouse anti-bovine CII antibodies their serum. No clear cut differences expression T cell receptor (TCR) V was observed between d- mice. Mechanisms underlying protective may shed light how HLA-DR molecules influence human RA.