Angiotensin II attenuates renal cortical cyclooxygenase-2 expression.

摘要: We have previously shown that in rat renal cortex, cyclooxygenase-2 (COX-2) expression is localized to cTALH cells the region of macula densa, and dietary salt restriction increases COX-2 expression. Administration angiotensin converting inhibitor, captopril, further increased mRNA cortical immunoreactivity, with most pronounced densa. an AT1 receptor antagonist, losartan, also significantly immunoreactivity. Mutant mice homozygous for both Agtr1a Agtr1b null mutations (Agtr1a–/–,Agtr1b–/–) demonstrated large immunoreactive inthe cTALH/macula To determine whether COX-2expression response ACE inhibition mediated renin production, rats were treated captopril one week or without specific SC58236. Plasma activity captropril group, this increase was inhibited by simultaneous treatment Thus, these studies indicated II inhibitors augment upregulation states volume depletion, suggesting negative feedback renin-angiotensin system modulates a mediator production angiotension production.