Hypoglycemia in children with type 1 diabetes: current issues and controversies.

摘要: Hypoglycemia is a common complication of insulin therapy, particularly in the young. For children and adolescents with diabetes, risk hypoglycemia may not only prevent optimal glycemic control but can also add significantly to psychosocial burden disease. Recently, surveys employing prospective monitoring techniques have allowed more precise information be gained about rates hypoglycemia, its clinical associations, impact new therapies technologies. A number reports estimated hypoglycemic comas convulsions approximately 20 events per 100 patient years on current conventional therapy. There evidence that introduction analog short- longer-acting insulins widespread use continuous subcutaneous infusion allow improvements occur without usual increased rate severe episodes. The glucose sensor technology has brought into focus occurrence asymptomatic hypoglycemia. Asymptomatic long been recognized, at night, when combination excessive action suppressed counter-regulatory hormone responses put special unawareness young associated an Whether episodes long-term consequences controversial. Early studies suggesting developing brain sensitive permanent neurological damage as result confirmed recent reports. Many found convincing sequelae are inevitable question, however, remains under active investigation. Continued become essential component diabetes management.