Absorption of drugs from the rat small intestine.

摘要: The relative rates of absorption a large number drugs have been measured by perfusing solutions through the entire small intestine anesthetized rat. A single perfusion differentiated very rapid from less absorption. continuous recirculation drug solution separated slow degree ionization an organic electrolyte in appears to be one most important factors determining its rat intestine. Acidic were rapidly absorbed if their pK 9s greater than 3. Basic 8. stronger acids and bases relatively slowly strong was imperceptible. Absorption can best explained assuming simple diffusion unionized across barrier which may lipoidal nature.