Varicella zoster virus and central nervous system syndromes.

摘要: Varicella zoster virus (VZV) causes chicken pox (varicella) after which it establishes latency and can subsequently reactivate to cause herpes zoster. Central nervous system (CNS) complications follow both primary infection reactivation of VZV. The more serious manifestations arise when VZV invades the spinal cord or cerebral arteries virus, causing diseases such as myelitis focal vasculopathies. International Herpes Management Forum (IHMF) has developed guidelines aid in diagnosis management CNS syndromes associated with these have focused on vasculopathy. new recommend that where vasculopathy is suspected, cerebrospinal fluid (CSF) should be analysed by polymerase chain reaction (PCR) for DNA. As antibodies may present CSF presence absence detectable DNA, also VZV-specific antibody if there a high likelihood disease. Early important, aggressive antiviral treatment effective. Patients treated intravenous aciclovir (10 mg/kg every 8 h adults, 500 mg/m2 body surface area children) 7 days. immunocompromised patient require longer treatment. However, discontinued negative results are obtained DNA anti-VZV CSF. Steroid therapy (prednisone 60-80 mg/day 3-5 days) considered reduce inflammation.