Diagnostic assays for polyomavirus JC and progressive multifocal leukoencephalopathy.

摘要: Progressive multifocal leukoencephalopathy (PML) is a devastating and often fatal demyelinating disease of the central nervous system for which effective therapies are lacking. It caused by replication polyomavirus JC (JCV) in oligodendrocytes astrocytes leading to their cytolytic death loss myelin from subcortical white matter. While virus very common human populations worldwide, incidence low confined almost exclusively individuals with some form immunological dysfunction. However, number people who constitute at-risk population growing larger includes HIV-1/AIDS patients receiving immunomodulatory such as multiple sclerosis treated natalizumab. Further adding public health significance this difficulties encountered diagnosis PML lack useful biomarkers progression. In review, we examine diagnostic assays that available different aspects JCV life cycle, usefulness drawbacks, prospects improvements.