Effects of diltiazem on perioperative ischemia, arrhythmias, and myocardial function in patients undergoing elective coronary bypass grafting.
作者： Rainald Seitelberger , Waltraud Hannes , Mark Gleichauf , Matthias Keilich , Marion Christoph
DOI: 10.1016/S0022-5223(94)70337-X
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摘要: Abstract A prospective, randomized study was performed on 120 patients undergoing elective coronary bypass grafting to define the effect of calcium channel blocker diltiazem perioperative ischemia, arrhythmias, and myocardial function. Patients received a continuous 24-hour infusion either (0.1 mg/kg per hour, n = 60) or nitroglycerin (1 μg/kg minute, 60). Perioperative monitoring included hemodynamic measurements, three-channel Holter monitoring, repeated assessment 12-lead electrocardiograms, analysis ischemia-specific laboratory parameters (creatine kinase, creatine kinase-MB, kinase-MB-mass troponin-T). Global regional systolic function diastolic compliance were assessed by means transesophageal echocardiography. The two groups did not differ with respect preoperative operative data. Except for significant reduction in heart rate, had no influence parameters. number (17 ± 9 versus 25 5, p
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