Translational Cellular Models of Breast Cancer Progression and Outcome

摘要: Breast cancer heterogeneity reflects considerable complexity underlying causality and disease progression. In vitro models composed of live-cell populations, maintained in the laboratory as cell cultures, are indispensable tools for in-depth biological characterization breast cancer. Cell cultures also serve surrogate functional response to physical chemical elements other types that coexist tumor microenvironment. Over past four decades, a limited subset rare spontaneously immortalized lines has provided critical starting material vast majority basic analytical studies Employing additional sources cells together with new high-throughput, high-dimensional assays improved patient prognostication. Concurrently, advances propagation patient-derived representing full spectrum subclass, subtype, stage malignant will be instrumental optimization next-generation preclinical better predict outcome expensive long-term clinical trials expediting drug discovery. Ultimately, successful targeting deterministic cellular aberrations within patients' own test systems could guide implementation individualized treatment prevention measures.