Gastrointestinal proliferation and aging

摘要: The gastrointestinal tract represents an organ system that is characterized by rapid proliferation and cells demonstrate differentiation from immature stem to terminal differentiated mature cells. Aging tissues illustrate markedly different phenomena aged post-mitotic Contrary generally held prejudices, a state of hyperproliferation, not hypoproliferation, occurs in the epithelial stomach, small intestine, large intestine stable-fed, rodents when compared young rodents. Furthermore, abnormalities proliferative responses become evident are stimulated injury, or starvation refeeding. We speculate such changes expose aging genotoxic effects may increase susceptibility cancers.