Genotoxicity Evaluation of Propyl-Propane-Thiosulfinate (PTS) from Allium genus Essential Oils by a Combination of Micronucleus and Comet Assays in Rats
作者： Antonio Cascajosa-Lira , María Puerto , Ana I Prieto , Silvia Pichardo , Leticia Díez-Quijada Jiménez
关键词:
摘要: Propyl-propanethiosulfinate (PTS) is a component of Allium essential oils. This organosulfur molecule can be used as feed additive to decrease the appearance bacterial resistances caused by residues antibiotics. In previous in vitro genotoxicity studies, contradictory results were reported for PTS. this work, vivo PTS male and female rats was assessed first time, following OECD (Organisation Economic Co-operation Development) guidelines. After oral administration (doses: 5.5, 17.4, 55.0 mg/kg body weight), combination micronucleus (MN) assay (OECD 474) bone marrow standard enzyme-modified comet 489) performed. necropsy, histopathological studies also carried out. The did not show at any doses assayed, revealed absence increased MN, DNA strand breaks or oxidative damage assays. study that only highest dose tested (55.0 mg/kg) liver all groups stomach presented minimal pathological lesions organs studied. Consequently, present work confirms genotoxic it promising natural alternative synthetic preservatives antibiotics animal feed.
mdpi.com
sci-hub.st 参考文章(33)
Pilar Mellado-García, Sara Maisanaba, María Puerto, Ana Isabel Prieto, Ricard Marcos, Silvia Pichardo, Ana María Cameán, In vitro toxicological assessment of an organosulfur compound from Allium extract: Cytotoxicity, mutagenicity and genotoxicity studies Food and Chemical Toxicology. ,vol. 99, pp. 231- 240 ,(2017) , 10.1016/J.FCT.2016.12.007
Shivraj Hariram Nile, Arti Shivraj Nile, Young Soo Keum, Kavita Sharma, None, Utilization of quercetin and quercetin glycosides from onion (Allium cepa L.) solid waste as an antioxidant, urease and xanthine oxidase inhibitors. Food Chemistry. ,vol. 235, pp. 119- 126 ,(2017) , 10.1016/J.FOODCHEM.2017.05.043
, Guido Rychen, Gabriele Aquilina, Giovanna Azimonti, Vasileios Bampidis, Maria de Lourdes Bastos, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Gerhard Flachowsky, Jürgen Gropp, Boris Kolar, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Alberto Mantovani, Baltasar Mayo, Fernando Ramos, Maria Saarela, Roberto Edoardo Villa, Robert John Wallace, Pieter Wester, Montserrat Anguita, Bruno Dujardin, Jaume Galobart, Matteo Lorenzo Innocenti, Guidance on the assessment of the safety of feed additives for the consumer. EFSA Journal. ,vol. 15, pp. 1- 17 ,(2017) , 10.2903/J.EFSA.2017.5022
María Llana-Ruiz-Cabello, Silvia Pichardo, José María Bermudez, Alberto Baños, Juan José Ariza, Enrique Guillamón, Susana Aucejo, Ana M Cameán, None, Characterisation and antimicrobial activity of active polypropylene films containing oregano essential oil and Allium extract to be used in packaging for meat products. Food Additives and Contaminants Part A-chemistry Analysis Control Exposure & Risk Assessment. ,vol. 35, pp. 782- 791 ,(2018) , 10.1080/19440049.2017.1422282
Antonio Sorlozano-Puerto, Maria Albertuz-Crespo, Isaac Lopez-Machado, Juan Jose Ariza-Romero, Alberto Baños-Arjona, Manuela Exposito-Ruiz, Jose Gutierrez-Fernandez, In Vitro Antibacterial Activity of Propyl-Propane-Thiosulfinate and Propyl-Propane-Thiosulfonate Derived from Allium spp. against Gram-Negative and Gram-Positive Multidrug-Resistant Bacteria Isolated from Human Samples BioMed Research International. ,vol. 2018, pp. 7861207- ,(2018) , 10.1155/2018/7861207
Predrag Putnik, Domagoj Gabrić, Shahin Roohinejad, Francisco J. Barba, Daniel Granato, Kumar Mallikarjunan, José M. Lorenzo, Danijela Bursać Kovačević, An overview of organosulfur compounds from Allium spp.: From processing and preservation to evaluation of their bioavailability, antimicrobial, and anti-inflammatory properties. Food Chemistry. ,vol. 276, pp. 680- 691 ,(2019) , 10.1016/J.FOODCHEM.2018.10.068
Teresa Vezza, Francesca Algieri, José Garrido‐Mesa, María Pilar Utrilla, María Elena Rodríguez‐Cabezas, Alberto Banos, Enrique Guillamón, Federico García, Alba Rodríguez‐Nogales, Julio Gálvez, None, The Immunomodulatory Properties of Propyl-Propane Thiosulfonate Contribute to its Intestinal Anti-Inflammatory Effect in Experimental Colitis. Molecular Nutrition & Food Research. ,vol. 63, pp. 1800653- ,(2019) , 10.1002/MNFR.201800653
David Kirkland, Dan D. Levy, Matthew J. LeBaron, Marilyn J. Aardema, Carol Beevers, Javed Bhalli, George R. Douglas, Patricia A. Escobar, Christopher S. Farabaugh, Melanie Guerard, George E. Johnson, Rohan Kulkarni, Frank Le Curieux, Alexandra S. Long, Jasmin Lott, David P. Lovell, Mirjam Luijten, Francesco Marchetti, John J. Nicolette, Stefan Pfuhler, Daniel J. Roberts, Leon F. Stankowski, Veronique Thybaud, Sandy K. Weiner, Andrew Williams, Kristine L. Witt, Robert Young, A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 839, pp. 21- 35 ,(2019) , 10.1016/J.MRGENTOX.2019.01.007
Alberto Baños, J. David García, Cristina Núñez, Nuria Mut-Salud, Samir Ananou, Manuel Martínez-Bueno, Mercedes Maqueda, Eva Valdivia, Subchronic toxicity study in BALBc mice of enterocin AS-48, an anti-microbial peptide produced by Enterococcus faecalis UGRA10 Food and Chemical Toxicology. ,vol. 132, pp. 110667- ,(2019) , 10.1016/J.FCT.2019.110667
Hans-Joerg Martus, Roland Froetschl, Bhaskar Gollapudi, Masamitsu Honma, Francesco Marchetti, Stefan Pfuhler, Rita Schoeny, Yoshifumi Uno, Carole Yauk, David J. Kirkland, Summary of major conclusions from the 7th International Workshop on Genotoxicity Testing (IWGT), Tokyo, Japan. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 852, pp. 503134- ,(2020) , 10.1016/J.MRGENTOX.2020.503134