Radon and lung cancer risk: taking stock at the millenium.

摘要: Abstract Radon is a well-established human carcinogen for which extensive data are available, extending into the range of exposures experienced by general population. Mounting epidemiologic evidence on radon and lung cancer risk, now available from more than 20 different studies underground miners complementary laboratory findings, indicates that risks linear in exposure without threshold. Radon also ubiquitous indoor air pollutant homes, risk projections imply second leading cause after smoking. Recommended control strategies United States other countries, include testing most homes mitigation those exceeding guideline levels, have been controversial. Further research needed, drawing molecular cellular approaches continuing follow-up miner cohorts, scientists should work toward constructing mechanistically based models combine experimental to yield estimates with enhanced certainty.