AUGMENTATION OF T CELL EXPANSION FOR ADOPTIVE IMMUNOTHERAPY BY ALTERNATE GAMMA CHAIN CYTOKINES AND BY GEMCITABINE MEDIATED INHIBITION OF MYELOID DERIVED SUPPRESSOR CELLS

Thomas H. Inge, Carl W. McCrady, Todd M. Tuttle, Mozhdeh Salour, Harry D. Bear, γ-Interferon Plays a Key Role in T-Cell-induced Tumor Regression Cancer Research. ,vol. 53, pp. 833- 839 ,(1993)

Anna K Nowak, Bruce W S Robinson, Richard A Lake, Gemcitabine Exerts a Selective Effect on the Humoral Immune Response Implications for Combination Chemo-immunotherapy Cancer Research. ,vol. 62, pp. 2353- 2358 ,(2002)

Sergei Kusmartsev, Dmitry I. Gabrilovich, STAT1 Signaling Regulates Tumor-Associated Macrophage-Mediated T Cell Deletion The Journal of Immunology. ,vol. 174, pp. 4880- 4891 ,(2005) , 10.4049/JIMMUNOL.174.8.4880

Sergei Kusmartsev, Yulia Nefedova, Daniel Yoder, Dmitry I. Gabrilovich, Antigen-specific inhibition of CD8+ T cell response by immature myeloid cells in cancer is mediated by reactive oxygen species. Journal of Immunology. ,vol. 172, pp. 989- 999 ,(2004) , 10.4049/JIMMUNOL.172.2.989

E. Appella, Y. Kawakami, S. Southwood, S. A. Rosenberg, P. F. Robbins, K. Sakaguchi, A. Sette, S. Eliyahu, C. Jennings, Xiaoqiang Kang, Recognition of multiple epitopes in the human melanoma antigen gp100 by tumor-infiltrating T lymphocytes associated with in vivo tumor regression. Journal of Immunology. ,vol. 154, pp. 3961- 3968 ,(1995)

G R Pettit, A H Esa, M K Silanskis, W S May, A D Hess, Activation of human T lymphocytes by bryostatin. Journal of Immunology. ,vol. 141, pp. 3263- 3269 ,(1988)

Roger Moe, Mary L. Disis, Ann E. Murphy, Robert B. Livingston, Margit Jeschke, Elaine McGlynn, Wei Chen, Martin A. Cheever, Emanuel Calenoff, Graham McLaughlin, Nick Lydon, Bernd Groner, Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Research. ,vol. 54, pp. 16- 20 ,(1994)

Suyu Shu, T. Chou, S. A. Rosenberg, Generation from tumor-bearing mice of lymphocytes with in vivo therapeutic efficacy. Journal of Immunology. ,vol. 139, pp. 295- 304 ,(1987)

J D Cornpropst, T J Brown, M Hamilton, L A Shipley, W D Daniels, H W Culp, Metabolism and disposition of gemcitabine, and oncolytic deoxycytidine analog, in mice, rats, and dogs. Drug Metabolism and Disposition. ,vol. 20, pp. 849- 855 ,(1992)

Sasa Radoja, Alan B. Frey, Cancer-induced defective cytotoxic T lymphocyte effector function: another mechanism how antigenic tumors escape immune-mediated killing. Molecular Medicine. ,vol. 6, pp. 465- 479 ,(2000) , 10.1007/BF03401788