The Pathogenic Role of Pemphigus Antibodies and Proteinase in Epidermal Acantholysis
作者： Shinji Morioka , Katsuichi Naito , Hideoki Ogawa
DOI: 10.1111/1523-1747.EP12519988
关键词:
摘要: The pathogenic role of pemphigus autoantibodies and proteinases in epidermal acantholysis has been studied organ cultures normal human skin. Dose-dependent occurred skin explants cultured medium containing 2–30mg/ml γ -globulin from serum. Acantholysis was not seen with 2mg/ml although antibody binding to the epidermis observed. Some degenerative changes addition were present when 30mg/ml added medium. N,ethylmaleimide(NEM) ethylene diamine tetraacetate(EDTA) prevented culture. Soybean trypsin inhibitor pepstatin had no effect on but they did inhibit vitro . Our results suggest that pemphigus-induced may be caused by at least 2 different types enzyme.
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