作者: Fabián Pardo , Roberto Villalobos-Labra , Bastián Sobrevia , Fernando Toledo , Luis Sobrevia
DOI: 10.1016/J.MAM.2017.11.010
关键词:
摘要: Cell-to-cell communication happens via diverse mechanisms including the synthesis, release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles (i.e., exosomes) microvesicles, apoptotic bodies. The amount cargo released EVs, which consist microRNAs (miRNAs), mRNA, proteins, DNA, among other molecules, are altered in obesity diabetes mellitus. from these diseases show with several miRNAs enrichment molecules involved inflammation, immune efficiency, cell activation. role regards adipocytes-released that may end a systemic insulin resistance. In mellitus, exosomes signal transform normal phenotype into diabetic endothelial cells. evidence as modulators function is increasing; however, it still unclear whether or microvesicles trustable useful marker for diagnose early detection this review, we summarise reported information regarding involvement obesity, T1 T2 gestational We emphasise fact studies addressing potential effect mellitus on severity done patients suffering simultaneously both diseases, i.e., diabesity. Unfortunately, lack biological effects makes difficult understand perhaps diseases.