Extracellular vesicles in obesity and diabetes mellitus

作者: Fabián Pardo , Roberto Villalobos-Labra , Bastián Sobrevia , Fernando Toledo , Luis Sobrevia

DOI: 10.1016/J.MAM.2017.11.010

关键词:

摘要: Cell-to-cell communication happens via diverse mechanisms including the synthesis, release and transfer to target cells of extracellular vesicles (EVs). EVs include nanovesicles (i.e., exosomes) microvesicles, apoptotic bodies. The amount cargo released EVs, which consist microRNAs (miRNAs), mRNA, proteins, DNA, among other molecules, are altered in obesity diabetes mellitus. from these diseases show with several miRNAs enrichment molecules involved inflammation, immune efficiency, cell activation. role regards adipocytes-released that may end a systemic insulin resistance. In mellitus, exosomes signal transform normal phenotype into diabetic endothelial cells. evidence as modulators function is increasing; however, it still unclear whether or microvesicles trustable useful marker for diagnose early detection this review, we summarise reported information regarding involvement obesity, T1 T2 gestational We emphasise fact studies addressing potential effect mellitus on severity done patients suffering simultaneously both diseases, i.e., diabesity. Unfortunately, lack biological effects makes difficult understand perhaps diseases.

参考文章(86)
Shafrir E, Development and consequences of insulin resistance: lessons from animals with hyperinsulinaemia. Diabetes & Metabolism. ,vol. 22, pp. 122- 131 ,(1996)
Jeong-Eun Lee, Pyong-Gon Moon, In-Kyu Lee, Moon-Chang Baek, None, Proteomic Analysis of Extracellular Vesicles Released by Adipocytes of Otsuka Long-Evans Tokushima Fatty (OLETF) Rats Protein Journal. ,vol. 34, pp. 220- 235 ,(2015) , 10.1007/S10930-015-9616-Z
G Togliatto, P Dentelli, M Gili, S Gallo, C Deregibus, E Biglieri, A Iavello, E Santini, C Rossi, A Solini, G Camussi, M F Brizzi, Obesity reduces the pro-angiogenic potential of adipose tissue stem cell-derived extracellular vesicles (EVs) by impairing miR-126 content: impact on clinical applications International Journal of Obesity. ,vol. 40, pp. 102- 111 ,(2016) , 10.1038/IJO.2015.123
Yaqin Zhang, Li Shi, Hongliang Mei, Jiexin Zhang, Yunxia Zhu, Xiao Han, Dalong Zhu, Inflamed macrophage microvesicles induce insulin resistance in human adipocytes Nutrition & Metabolism. ,vol. 12, pp. 21- 21 ,(2015) , 10.1186/S12986-015-0016-3
Alain Stepanian, Laure Bourguignat, Sabiha Hennou, Muriel Coupaye, David Hajage, Laurence Salomon, Marie-Christine Alessi, Simon Msika, Dominique de Prost, Microparticle increase in severe obesity: Not related to metabolic syndrome and unchanged after massive weight loss Obesity. ,vol. 21, pp. 2236- 2243 ,(2013) , 10.1002/OBY.20365
Mariëtte E.G. Kranendonk, Frank L.J. Visseren, Bas W.M. van Balkom, Esther N.M. Nolte-'t Hoen, Joost A. van Herwaarden, Wilco de Jager, Henk S. Schipper, Arjan B. Brenkman, Marianne C. Verhaar, Marca H.M. Wauben, Eric Kalkhoven, Human adipocyte extracellular vesicles in reciprocal signaling between adipocytes and macrophages. Obesity. ,vol. 22, pp. 1296- 1308 ,(2014) , 10.1002/OBY.20679
Laura Esposito, Kara M. D. Hunter, Jan Clark, Daniel B. Rainbow, Helen Stevens, Jennifer Denesha, Simon Duley, Sarah Dawson, Gillian Coleman, Sarah Nutland, Gwynneth L. Bell, Carla Moran, Marcin Pekalski, John A. Todd, Linda S. Wicker, Investigation of Soluble and Transmembrane CTLA-4 Isoforms in Serum and Microvesicles Journal of Immunology. ,vol. 193, pp. 889- 900 ,(2014) , 10.4049/JIMMUNOL.1303389
Shivakumar Keerthikumar, David Chisanga, Dinuka Ariyaratne, Haidar Al Saffar, Sushma Anand, Kening Zhao, Monisha Samuel, Mohashin Pathan, Markandeya Jois, Naveen Chilamkurti, Lahiru Gangoda, Suresh Mathivanan, ExoCarta: A Web-Based Compendium of Exosomal Cargo Journal of Molecular Biology. ,vol. 428, pp. 688- 692 ,(2016) , 10.1016/J.JMB.2015.09.019
Alexander J. Lakhter, Emily K. Sims, Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders Molecular Endocrinology. ,vol. 29, pp. 1535- 1548 ,(2015) , 10.1210/ME.2015-1206