Functional and diffusion MRI reveal the neurophysiological basis of neonates’ noxious-stimulus evoked brain activity

摘要: Understanding the neurophysiology underlying neonatal responses to noxious stimulation is central improving early life pain management. In this multimodal MRI study, we use resting-state and diffusion investigate inter-individual variability in noxious-stimulus evoked brain activity. We observe that cerebral haemodynamic experimental can be predicted from separately acquired activity (n = 18). Applying prediction model independent Developing Human Connectome Project data (n = 215), identify negative associations between white matter mean diffusivity. These are subsequently confirmed original paradigm dataset, validating model. Here, healthy neonates coupled microstructure, neural features used predict stimulation, dHCP dataset could utilised for future exploratory research of system neurophysiology. The neurophysiological basis poorly understood. Using MRI, authors neonates’ both their network microstructure.