The role of HLA-G for protection of human renal cell–carcinoma cells from immune-mediated lysis: implications for immunotherapies

摘要: HLA-G as a non-classical MHC class I molecule exhibits limited tissue distribution and exerts multiple immune regulatory functions including the induction of tolerance. In addition, has been detected in some tumors different histology therefore may represent novel escape mechanism tumor cells. Despite immunogenicity renal cell carcinoma (RCC), outgrowth cells occurs which might be attributable to abrogation efficient anti-tumor responses. We here review potential role RCC immunology, expression pattern its functional consequences on A heterogenous constitutive interferon- inducible mRNA protein was found lines lesions, but not autologous normal kidney epithelium. transcription at high frequency primary lesions lines. Functional studies performed with alloreactive natural lymphokine activated killer well antigen-specific CD8 + T populations demonstrated that inhibits lysis by these effector cells, whereas − were recognized. Thus, aberrant participate evasion from immunosurveillance. © 2003 Elsevier Science Ltd. All rights reserved.