Potassium-stimulated angiotensin release from superfused adrenal capsules and enzymatically dispersed cells of the zona glomerulosa.

摘要: The cells of the adrenal cortex contain angiotensin-II (All), but whether this peptide is synthesized there (vs. internalized from systemic circulation), it secreted, and important in aldosterone production remain uncertain. To address these issues, we studied AI AII release superfused rat capsules dispersed glomerulosa cells. Superfused released 7-fold more 270 min than originally contained (495 ± 101 fmol AII/rat vs. 66 8 tissue content). amount same period only slightly exceeded content. In response to higher potassium concentrations medium (9 3.6 mM K+), both significantly into superfusate. This was oscillatory. oscillations occurred each 15 experiments, with a 45–90 min. Decapsulated glands (the zona faciculata/reticul...