Evidence of an inhibitory restraint of seizure activity in humans

摘要: The location and trajectory of seizure activity is great importance, yet our ability to map such remains primitive. Recently, the development multi-electrode arrays for use in humans has provided new levels temporal spatial resolution recording seizures. Here, we show that there a sharp delineation between areas showing intense, hypersynchronous firing indicative recruitment seizure, adjacent territories where only low-level, unstructured firing. Thus, core territory recruited neurons surrounding 'ictal penumbra'. defining feature penumbra' contrast large amplitude EEG signals low-level there. Our human recordings bear striking similarities with animal studies an inhibitory restraint, indicating they can be readily understood terms this mechanism. These findings have important implications how localize its spread.