Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9

摘要: There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis angiogenesis. Inhibition of u-PA MMPs could suppress migration invasion cells. Berberine, one the main constituents plant Rhizoma coptidis, a type isoquinoline alkaloid, reported to have anti-cancer effects different human cell lines. however, no available information on berberine tongue Here, we report inhibited SCC-4 squamous carcinoma This action was mediated by p-JNK, p-ERK, p-p38, IκK NF-κB signaling pathways resulting inhibition MMP-2 -9 Our Western blowing analysis also showed levels urokinase-plasminogen (u-PA). These results suggest down-regulates u-PA, expressions cells through FAK, IKK novel function inhibit invasive capacity malignant