Acoustic Wave Study of Interfacially-Bound Proteins, Nucleic Acids and Blood Platelets

摘要: Acoustic wave devices of the transverse type offer tremendous potential for study biochemical macromolecules and cells imposed at sensor liquid interface. Although this category biosensor is conventionally thought as a detector only, device can also impart important structural other information. The reason lies in fact that such species are present on surface precisely location where solid-liquid coupling occurs. This means interfacial structure entities alter propagation acoustic energy an exquisitely sensitive manner. With regard to protein adsorption, competitive binding blood proteins antibodies surfaces displaying different will be described. Such processes role played by polymers biocompatability cardiovascular breast implants. Our results indicate complete reevaluation some accepted concepts area, including well-known Vorman effect, warranted. Also with respect haematology adhesion platelets various surface-bound receptors discussed. In case responds viscoelastic properties rather than mass. most recent work HIV transcriptional chemistry evaluated. Not only does sensitively detect peptide small molecule binding, but effects caused moieties discriminated. Finally, use enzymes real-time regeneration singlestrand DNA attached TSMs