Accumulation of Squalene in a Microalga Chlamydomonas reinhardtii by Genetic Modification of Squalene Synthase and Squalene Epoxidase Genes
作者： Masataka Kajikawa , Seiko Kinohira , Akira Ando , Miki Shimoyama , Misako Kato
DOI: 10.1371/JOURNAL.PONE.0120446
关键词:
摘要: … that the partial suppression of CrSQE expression is an effective strategy to increase squalene accumulation. A feasible strategy to accumulate still higher levels of squalene in cells is to …
paperity.org
harvard.edu参考文章(52)
Won-Kyung Hong, Sun-Yeon Heo, Hye-Mi Park, Chul Ho Kim, Jung-Hoon Sohn, Akihiko Kondo, Jeong-Woo Seo, Characterization of a Squalene Synthase from the Thraustochytrid Microalga Aurantiochytrium sp. KRS101 Journal of Microbiology and Biotechnology. ,vol. 23, pp. 759- 765 ,(2013) , 10.4014/JMB.1212.12023
P. Bhattacharjee, V.B. Shukla, R.S. Singhal, P.R. Kulkarni, Studies on fermentative production of squalene World Journal of Microbiology & Biotechnology. ,vol. 17, pp. 811- 816 ,(2001) , 10.1023/A:1013573912952
G. Jiang, T.L. McKenzie, D.G. Conrad, I. Shechter, Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase Journal of Biological Chemistry. ,vol. 268, pp. 12818- 12824 ,(1993) , 10.1016/S0021-9258(18)31461-3
Rachida Kribii, Montserrat Arro, Ana Arco, Victor Gonzalez, Lluis Balcells, Didier Delourme, Albert Ferrer, Francis Karst, Albert Boronat, Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway. FEBS Journal. ,vol. 249, pp. 61- 69 ,(1997) , 10.1111/J.1432-1033.1997.00061.X
Attila Molnar, Andrew Bassett, Eva Thuenemann, Frank Schwach, Shantanu Karkare, Stephan Ossowski, Detlef Weigel, David Baulcombe, Highly specific gene silencing by artificial microRNAs in the unicellular alga Chlamydomonas reinhardtii Plant Journal. ,vol. 58, pp. 165- 174 ,(2009) , 10.1111/J.1365-313X.2008.03767.X
Miroslava Spanova, Günther Daum, Squalene - biochemistry, molecular biology, process biotechnology, and applications European Journal of Lipid Science and Technology. ,vol. 113, pp. 1299- 1320 ,(2011) , 10.1002/EJLT.201100203
Ian K. Blaby, Crysten E. Blaby-Haas, Nicolas Tourasse, Erik F.Y. Hom, David Lopez, Munevver Aksoy, Arthur Grossman, James Umen, Susan Dutcher, Mary Porter, Stephen King, George B. Witman, Mario Stanke, Elizabeth H. Harris, David Goodstein, Jane Grimwood, Jeremy Schmutz, Olivier Vallon, Sabeeha S. Merchant, Simon Prochnik, The Chlamydomonas genome project: a decade on Trends in Plant Science. ,vol. 19, pp. 672- 680 ,(2014) , 10.1016/J.TPLANTS.2014.05.008
Martin Lohr, Jörg Schwender, Jürgen E.W. Polle, Isoprenoid biosynthesis in eukaryotic phototrophs: A spotlight on algae Plant Science. ,vol. 185, pp. 9- 22 ,(2012) , 10.1016/J.PLANTSCI.2011.07.018
L. Harivardhan Reddy, Patrick Couvreur, Squalene: A natural triterpene for use in disease management and therapy Advanced Drug Delivery Reviews. ,vol. 61, pp. 1412- 1426 ,(2009) , 10.1016/J.ADDR.2009.09.005
Kristy M. Brumfield, James V. Moroney, Thomas S. Moore, Tiffany A. Simms, David Donze, Functional Characterization of the Chlamydomonas reinhardtii ERG3 Ortholog, a Gene Involved in the Biosynthesis of Ergosterol PLoS ONE. ,vol. 5, pp. e8659- ,(2010) , 10.1371/JOURNAL.PONE.0008659