A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.
作者： M Ban , G J Stewart , B H Bennetts , R Heard , R Simmons
关键词:
摘要: The role of genetic factors in determining susceptibility to multiple sclerosis is well established but, despite the global distribution disease, systematic efforts locate genes have concentrated exclusively on populations from Northern Hemisphere. We performed a genome wide screen linkage Australian population using panel 397 microsatellite markers 54 affected sibling-pairs. Multipoint analysis revealed four regions suggestive (on chromosomes 2p13, 4q26-28, 6q26 and Xp11) 18 additional potential (at 1q43-44, 3q13-24, 4q24, 4q31-34, 5q11-13, 6q27, 7q33-35, 8p23-21, 9q21, 13q31-32, 16p13, 16p11, 16q23-24, 17p13, 18p11, 20p12-11, Xp21-11 Xq23-28). Our results contribute available data adding new provisional as increasing support for areas previously implicated sclerosis.
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