Personalized treatment for colorectal cancer: novel developments and putative therapeutic strategies

作者: Jamil Akkad , Sylvia Bochum , Uwe M. Martens

DOI: 10.1007/S00423-015-1276-0

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摘要: Background Colorectal cancer (CRC) is the third most common diagnosed worldwide and continues to be a major healthcare concern. Molecular heterogeneity of CRC believed one main factors responsible for considerable variability in treatment response. With recent development powerful genomic technologies, novel insights tumor biology have now been provided, facilitating recognition new molecular subtypes with prognostic predictive implications.

参考文章(130)
Paul Roepman, Andreas Schlicker, Josep Tabernero, Ian Majewski, Sun Tian, Victor Moreno, Mireille H Snel, Christine M Chresta, Robert Rosenberg, Ulrich Nitsche, Teresa Macarulla, Gabriel Capella, Ramon Salazar, George Orphanides, Lodewyk FA Wessels, Rene Bernards, Iris M Simon, None, Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition International Journal of Cancer. ,vol. 134, pp. 552- 562 ,(2014) , 10.1002/IJC.28387
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
S. Kopetz, J. Desai, E. Chan, J. R. Hecht, P. J. O'Dwyer, R. J. Lee, K. B. Nolop, L. Saltz, PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors. Journal of Clinical Oncology. ,vol. 28, pp. 3534- 3534 ,(2010) , 10.1200/JCO.2010.28.15_SUPPL.3534
Heidi Schwarzenbach, Dave S. B. Hoon, Klaus Pantel, Cell-free nucleic acids as biomarkers in cancer patients Nature Reviews Cancer. ,vol. 11, pp. 426- 437 ,(2011) , 10.1038/NRC3066
Yosef Yarden, Mark X. Sliwkowski, Untangling the ErbB signalling network Nature Reviews Molecular Cell Biology. ,vol. 2, pp. 127- 137 ,(2001) , 10.1038/35052073
Aurélien de Reyniès, Valérie Boige, Gérard Milano, Jean Faivre, Pierre Laurent-Puig, KRAS mutation signature in colorectal tumors significantly overlaps with the cetuximab response signature. Journal of Clinical Oncology. ,vol. 26, pp. 2228- 2230 ,(2008) , 10.1200/JCO.2007.15.9186
Yvette Schwitalle, Matthias Kloor, Susanne Eiermann, Michael Linnebacher, Peter Kienle, Hanns Peter Knaebel, Mirjam Tariverdian, Axel Benner, Magnus von Knebel Doeberitz, Immune Response Against Frameshift-Induced Neopeptides in HNPCC Patients and Healthy HNPCC Mutation Carriers Gastroenterology. ,vol. 134, pp. 988- 997 ,(2008) , 10.1053/J.GASTRO.2008.01.015
Zi-Xu Yuan, Xiao-Yan Wang, Qi-Yuan Qin, De-Feng Chen, Qing-Hua Zhong, Lei Wang, Jian-Ping Wang, The Prognostic Role of BRAF Mutation in Metastatic Colorectal Cancer Receiving Anti-EGFR Monoclonal Antibodies: A Meta-Analysis PLoS ONE. ,vol. 8, pp. e65995- ,(2013) , 10.1371/JOURNAL.PONE.0065995
J Souglakos, J Philips, R Wang, S Marwah, M Silver, M Tzardi, J Silver, S Ogino, S Hooshmand, E Kwak, E Freed, J A Meyerhardt, Z Saridaki, V Georgoulias, D Finkelstein, C S Fuchs, M H Kulke, R A Shivdasani, Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. British Journal of Cancer. ,vol. 101, pp. 465- 472 ,(2009) , 10.1038/SJ.BJC.6605164