⁹⁹mTc-HYNIC-MPG: a novel SPECT probe for targeting mutated EGFR.
作者： Yan Yan , Zun-Yu Xiao , Yan Song , Zhao-Ting Kang , Ping Wang
DOI: 10.1016/J.BMCL.2014.12.074
关键词:
摘要: Mutated epidermal growth factor receptor (EGFR) is an important biomarker for cancer diagnosis and molecular target many anticancer drugs. Localizing EGFR evaluating mutational status can help to identify patients who are potentially the most suitable ones targeted treatments. Hence, we developed a novel tyrosine kinase inhibitor labeled with (99m)Tc ((99m)Tc-HYNIC-MPG) evaluated its binding capacity in vitro vivo. This probe was synthesized by one-step method that simple highly efficient. Importantly, uptake rate (99m)Tc-HYNIC-MPG liver as low 28.44 ± 0.15% (mean SD, n=3). finding presents first time bind mutated efficiently thus provides tool detect suppress tumorigenesis.
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