Risk for Clostridium difficile infection after radical cystectomy for bladder cancer: Analysis of a contemporary series.

摘要: Abstract Introduction This study seeks to evaluate the incidence and associated risk factors of Clostridium difficile infection (CDI) in patients undergoing radical cystectomy (RC) for bladder cancer. Methods We retrospectively reviewed a single institution׳s cancer database including all who underwent RC between 2010 2013. CDI was diagnosed by detection toxin B gene using polymerase chain reaction–based stool assay with clinically significant diarrhea within 90 days index operation. A multivariable logistic regression model used identify demographics perioperative developing CDI. Results Of 552 RC, postoperative occurred 49 (8.8%) median time diagnosis after 7 (interquartile range: 5–19). 122 readmissions complications, 10% (n = 12) were related CDI; 2 died sepsis directly severe On multivariate regression, use chronic antacid therapy (odds ratio 1.9, 95% CI: 1.02–3.68, P 0.04) antibiotic exposure greater than 2.2, 1.11–4.44, 0.02) independently The preoperative antibiotics positive findings on urine culture 30 before surgery not statistically significantly development (P 0.06). Conclusions occurs 8.8% RC. Our demonstrates that long duration antimicrobial are Efforts focusing minimizing needed, prophylaxis guidelines should be followed.