Neurotrophic Natural Products: Chemistry and Biology
作者： Jing Xu , Michelle H. Lacoske , Emmanuel A. Theodorakis
关键词:
摘要: Neurodegenerative diseases and spinal cord injury affect approximately 50 million people worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous system growth factors, that is, neurotrophins, are a potential solution these disorders, since they could promote nerve regeneration. An average of 500 publications year attests significance neurotrophins in biomedical sciences underlines their for therapeutic applications. Nonetheless, poor pharmacokinetic profile severely restricts clinical use. On other hand, small molecules modulate neurotrophic activity offer promising approach against neurological disorders. Nature has provided an impressive array natural products have potent activities. This Review highlights current synthetic strategies toward compounds summarizes ability induce neuronal rehabilitation. It is anticipated be used not only as starting points drug design but also tools study next frontier sciences: brain map project.
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