Oncogenic potential of bcl-2 demonstrated by gene transfer

摘要: Follicular lymphoma is the most common human B-cell malignancy in United States and Western Europe1. Most of tumours contain t(14;18) chromosome translocations involving bcl-2 gene2–5. Translocation sequences from 18 into transcriptionally active immunoglobulin locus at band 14q32 B cells deregulates gene expression, resulting accumulation high levels messenger3. Human transcripts generate two proteins, p26 bcl-2-α p22 bcl-2-β, by virtue alternative splice-site selection2. Both proteins have their first 196 NH2-terminal amino acids but share little similarity with other a data bank2,4. Although biological biochemical functions are unknown, recent subcellular localization studies indi-cate that associates cellular membranes, con-sistent stretch hydrophobic its carboxy terminus1,2,6. The may represent novel oncogene having no known retroviral counterpart. Here we demonstrate oncogenic potential through transfer approach.