摘要: The pulpo-dentine complex is normally protected from exogenous substances in the oral cavity by overlying enamel or cementum. Dental caries, dental trauma, enamel/dentine cracks, and restorative procedures commonly breach integrity of cementum may allow infection to occur, possibly leading pulp periapical inflammatory disease. Infection intraradicular space a dynamic process involving interactions between host microbial factors. An understanding these factors has led development endodontic techniques that offer predictable success.