Brain Aging: Influence of Early–Life Events on Late-Life Brain Disorders

摘要: The prominent symptoms of Alzheimer’s disease (AD) include severe loss memory, failure cognition and reasoning, overall deficit other intellectual abilities. AD usually appears late in adult life, but when the initiates how long processes take to develop are presently unknown. To address this issue, “Latent Early–life Associated Regulation” (LEARn) model has been proposed. This explains etiology integrates both neuropathological features (e.g., amyloid-beta plaques hyperphosphorylated tau tangles) environmental conditions dietary imbalance, metal exposure, pestichemicals) associated with AD. As per LEARn model, agents could perturb gene regulation a long–term fashion, beginning at early developmental stages, these perturbations would not have pathological results until significantly later if an additional perturbation were occur. postulates latent expression specific genes triggered stage life. operates via regulatory region (promoter) gene, specifically through changes methylation oxidation status within promoter genes. Thus, unifies genetic risk factors explain most common, sporadic form Finally, possible medical remediation is discussed reference relatively term latency under model.