Thyroid Function During Catch-Up Growth: A Focus on the Growth Plate

摘要: Thyroid hormone (TH) has long been recognised as a potent regulator of skeletal maturation at the growth plate. The action TH interfaces not only with major regulatory pathways governing proliferation and differentiation chondrocytes plate but also mechanisms controlling extracellular matrix surrounding these cells. In addition, contributes to regulation catch-up in children other endocrine disorders, such those GH deficiency who are receiving rhGH treatment. Hypothyroidism childhood is almost invariably associated failure. Usually, after T4 replacement therapy initiated, specific abnormalities resolve period ensues. Some authors have shown that incomplete often occurs whom was initiated untreated hypothyroidism or during pubertal development. Recent data seem support hypothesis caused by delayed senescence. failure complete some patients for treatment may therefore result from fact their greater impact on rate than it does senescence plate, producing smaller clonal population proliferative zone resulting less efficient growth. acceleration oestrogen, an earlier exhaustion potential chondrocytes, play important role children.