Idiosyncratic reactions to antidepressants: A review of the possible mechanisms and predisposing factors

摘要: Abstract Antidepressants, a widely used group of drugs, are associated with the range idiosyncratic reactions affecting in particular liver, skin and both hematolotical central nervous systems. These seem to be mediated by chemically reactive metabolites formed cytochrome P450 enzyme system, toxicity occuring either directly or indirectly via an immune mechanism. Individual susceptibility is determined factors, genetic environmental, which result inadequate detoxication metabolite. Prevention such will depend on development new compounds not converted toxic prediction individual prior drug administration.