Reactive Oxygen and Nitrogen Species: Interactions with Mitochondria and Pathophysiology

摘要: A small proportion of the oxygen used by mitochondrial respiratory chain is partially reduced to superoxide, which then further metabolized hydrogen peroxide. In addition reactive species (ROS), nitric oxide synthase (NOS) produces ( NO • ) which, at low concentrations, controls respiration and biogenesis. At higher reacts with superoxide generate a family molecules known as nitrogen (RNS). levels, ROS contribute cell signaling RNS cause DNA, lipid, protein damage when uncontrolled and, bioenergetic failure in cardiovascular central nervous systems.