Plasma pharmacokinetics of alfaxalone in dogs after an intravenous bolus of Alfaxan-CD RTU

摘要: Abstract Objective To determine the pharmacokinetic parameters of alfaxalone in dogs after intravenous (IV) administration clinical and supra-clinical doses a 2-hydroxypropyl-beta-cyclodextrin (HPCD) formulation (Alfaxan-CD RTU). Experimental design Prospective two-period crossover design. Animals Eight (four male four female) young adult healthy Beagle dogs. Methods The steroid anaesthetic was administered IV at two (2 10 mg kg −1 ) with washout period 21 days. Blood samples were collected before up to 8 hours dosing. Plasma concentrations assayed using liquid chromatograph/mass selective detector technique analyzed estimate main by noncompartmental analysis. Results expressed as mean ± SD. duration anaesthesia from endotracheal intubation extubation 6.4 2.9 26.2 7.5 minutes, for 2 doses, respectively. plasma clearance differed statistically 59.4 12.9 52.9 12.8 mL minute , respectively ( p = 0.008) but this difference deemed clinically unimportant; harmonic terminal half-lives (t 1/2 24.0 1.9 37.4 1.6 minutes volume distribution between 3 L did not differ doses. No sex effect observed. Conclusions Clinical relevance Alfaxalone, an HPCD RTU) dog provides rapid smooth induction anaesthesia, satisfactory conditions short anaesthesia. There no significant modification sexes (10