Cyclic and Linear Monoterpenes in Phospholipid Membranes: Phase Behavior, Bilayer Structure, and Molecular Dynamics.

摘要: Monoterpenes are abundant in essential oils extracted from plants. These relatively small and hydrophobic molecules have shown important biological functions, including antimicrobial activity membrane penetration enhancement. The interaction between the monoterpenes lipid bilayers is considered to understanding of functions monoterpenes. In this study, we investigated effect cyclic linear on structure dynamics lipids model membranes. We studied ternary system 1,2-dimyristoyl-sn-glycero-3-phosphocholine-monoterpene-water as a with focus dehydrated conditions. By combining complementary techniques, differential scanning calorimetry, solid-state nuclear magnetic resonance, small- wide-angle X-ray scattering, bilayer structure, phase transitions, molecular were at different water contents. cause pronounced melting point depression segregation bilayers, extent these effects depends hydration addition amount thymol fluid (volume fraction 0.03 bilayer) leads an increased order acyl chain close interface. findings discussed relation systems formulations.