Methicillin-Resistant Staphylococcus aureus (MRSA) Nares Colonization at Hospital Admission and Its Effect on Subsequent MRSA Infection

摘要: Background. Asymptomatic colonization with methicillin-resistant Staphylococcus aureus (MRSA) has been described as a risk factor for subsequent MRSA infection. is an important nosocomial pathogen but currently reported in patients without typical factors acquisition. This study was designed to evaluate the impact of asymptomatic nares on development The incidence infection examined and or methicillin-susceptible S. (MSSA) at admission hospital those who developed during hospitalization. Methods. Patients admitted 5 representative units were prospectively evaluated. Nares samples obtained culture Laboratory results monitored identify all infections that occurred period 1 year thereafter. Results. Of 758 had cultures performed admission, 3.4% colonized MRSA, 21% MSSA. A total 19% 25% acquired hospitalization compared 1.5% 2.0% MSSA ( ) uncolonized ), respectively, admission. P ! .01 increased infection, (relative [RR], 13; 95% confidence interval [CI], 2.7‐64) no staphylococcal (RR, 9.5; CI, 3.6‐25) Acquisition also acquisition 12; 4.0‐38). Conclusion. nares, either present hospitalization, increases Identifying could target high-risk population may benefit from interventions decrease