Centrally located body fat is related to inflammatory markers in healthy postmenopausal women.

摘要: Menopause is a universal transition, marking an important stage in every woman’s life, associated with decreased estrogen and increased follicle-stimulating luteinizing hormones.1 Estrogen deficiency increasing age are body composition changes hence risk of metabolic syndrome that may lead to diseases such as atherosclerotic cardiovascular disease (CVD) diabetes. Postmenopausal women typically experience untoward fat distribution have garnered attention recently because they contribute CVD. Fat distributed two areas: the central or androidal region gluteal-femoral gynoidal region. promotes accumulation region2; correspondingly, postmenopausal plays role centrally deposited fat.3 This increase located greater than overall fat, including syndrome, non–insulin-dependent diabetes,4 heart disease,5,6 stroke.7 The location also major determining morbidity fat. Evidence indicates indices abdominal obesity, waist-to-hip ratio8 waist circumference,9 better predictors mass index (BMI) alone. Adipose tissue complex active secretory organ both transmits receives signals modulate energy expenditure, appetite, endocrine reproductive functions, insulin sensitivity, bone metabolism, inflammation, immunity.10 Due surfeit intake insufficient excess lipid adipose liver accumulates which turn can trigger chronic, subacute state causing inflammatory cells biochemical markers inflammation. Obesity-induced inflammation play development progression CVD type 2 diabetes. Adipose has been described metabolically organ, releasing proteins leptin adiponectin11; cytokines tumor necrosis factor α (TNF-α)12 interleukin (IL)-6,13 interleukin-1β (IL-1β)14; well acute-phase proteins, C-reactive protein (CRP) fibrinogen.15 Collectively, these hormones, cytokines, (adipocytokines adipokines) released from adipocytes, activated macrophages, other immune produce TNF-α, IL-6, IL-1β, although relative amount produced by each cell unclear.10 response emerges obesity seems be triggered reside predominantly tissue, critical sites involved.16 A decline ovarian function menopause increases proin-flammatory cytokines.17 exact mechanisms interferes cytokine activity still unknown but include interactions receptor transcription factors,18 modulation nitric oxide activity,19 antioxidant effects,20 plasma membrane actions,21 function.22 Clinical studies shown strong link between proinflammatory loss23,24 CVD.25 The main purpose this cross-sectional study was identify whether adiposity were related markers, specifically CRP, fibrinogen, determine more closely healthy women. Taking into account dietary we hypothesized would higher mass.