Anti-Inflammatory Effect of Violapyrones B and C from a Marine-derived Streptomyces sp.
作者： Hwa-Sun Lee , Bong-Jeun An , Hyeon Jeong Kim , Yong Hun Cho , Dong In Kim
DOI: 10.20307/NPS.2015.21.4.251
关键词:
摘要: Recently, we reported violapyrones B, C, H and I, unusual 3, 4, 6-trisubstituted α-pyrone derivatives, from the culture broth of marine Streptomyces sp. 112CH148. In previous studies, have been shown to antibacterial antitumor activities. However, anti-inflammatory effect has not yet. As part our ongoing study for discovery bioactive metabolites microorganisms, found that also activity. this study, investigated on LPS-induced inflammatory responses in vitro. Violapyrones B C did affect viability RAW 264.7 cells at concentrations up 25 μM. inhibited production NO compared control. addition, down-regulated expression iNOS protein LPS-stimulated cells. To best knowledge, is first report activity C. Keywords − Violapyrones, α-Pyrones, sp., Anti-inflammatory
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