Control of Enzyme Activity

摘要: This chapter discusses the way of controlling enzyme activity. All living organisms require a high degree control over metabolic processes so as to permit ordered change without precipitating catastrophic progress toward thermodynamic equilibrium. The parallel existence two irreversible reactions is greatest importance in which means that direction flux can be determined by differential activities enzymes. ordinary laws kinetics are inadequate for providing necessary metabolism. Instead, many enzymes at point display property responding with exceptional sensitivity changes metabolite concentrations. commonly known cooperativity. Although hemoglobin not an but transport protein, study binding oxygen it has contributed much understanding cooperativity would inappropriate discuss first discussing hemoglobin. There important physical difference between myoglobin and Myoglobin monomer, single polypeptide chain oxygen-binding site per molecule, tetramer, consisting four chains, or subunits, each site.