Shell/core differences in mu- and delta-opioid receptor modulation of dopamine efflux in nucleus accumbens.

摘要: Abstract The mu- and delta-opioid receptors located at the terminal level in nucleus accumbens are involved opiate modulation of dopamine release this brain area. However, recent studies suggest that effects opioid drugs on core subregion may completely differ from those observed shell. We used vivo microdialysis to simultaneously apply selective receptor agonists measure extracellular levels three subregions accumbens, namely shell, core, transition zone between them. regional analysis these demonstrated basal its metabolites were higher decreased Retrodialysis application both mu-receptor agonist ([ d -Ala 2 , N-Me-Phe 4 Gly 5 -ol]-enkephalin (DAMGO) (1 μmol/L)) -Pen ]-enkephalin (DPDPE) (50 nmol/L)) increased dialysate dopamine. shell significantly reduced subregion. Local same doses did not affect dialysates. These results circuits modulating dopaminergic activity could accumbens.