Radiation biology and oncology in the genomic era

摘要: Radiobiology research is building the foundation for applying genomics in precision radiation oncology. Advances high-throughput approaches will underpin increased understanding of radiosensitivity and development future predictive assays clinical application. There an established contribution genetics as a risk factor radiotherapy side effects. An individual's inherited polygenic trait with architecture that includes rare mutations few genes confer large effects common variants many small effects. Current thinking some be tissue specific, tests tailored to normal tissues at risk. The relationship between tumor cell poorly understood. Data are emerging suggesting interplay germline genetic variation epigenetic modification growing evidence changes DNA methylation regulate cancer cells histone acetyltransferase inhibitors have radiosensitizing Changes can also impair damage response signaling alter radiosensitivity. important effort advance radiobiology genomic era was establishment Radiogenomics Consortium enable creation cohorts required exploit advances genomics. To address challenges harmonizing data from multiple cohorts, consortium REQUITE project collect standardized genotyping ~5,000 patients. collection detailed dosimetric produce validated multivariable models. Continued efforts identify new impact on generate knowledge toxicity pathogenesis incorporate into decision-making process.