Synthesis of Some New 2-Methyl -1,4-benzothiazine-3(1H)- one Derivatives as Potential Vasodilators

摘要: The increase in the internal diameter of a blood vessel that results from relaxation smooth muscle within wall is vasodilation. This causes an flow and decrease systemic vascular resistance. Some substances produced by tissue deprived fresh seem to be responsible for dilation. Many products metabolism bring about action, CO2 acids are among them. Dilation vessels necessary restore local environment tissues normal metabolism. It may prove potential treatment different cardiac disorders like atherosclerosis, where, narrowed due deposition plaque cholesterol etc. 1,4-benzothiazines have been reported possess wide range pharmacological biological activities. Here, we report synthesis activity some new arylidenehydrazino-(1H)-1,4-benzothiazines. synthesized compounds were subjected prediction A software application (PASS) was used this purpose. relationship between structure activities studied it found arylidenehydrazino-(1H)-1,4-benzothiazines expected vasodilators.