The Role of Small t Antigen in SV40 Oncogenesis

作者: M. Carbone , F. Pompetti , C. Cicala , P. Nguyen , K. Dixon

DOI: 10.1007/978-1-4899-2563-3_11

关键词:

摘要: Simian virus 40 (SV 40) is an oncogenic papovavirus capable of inducing tumors in rodents and transforming cells from many species tissue culture (Topp, et al. 1981). Due to the small size its genome, about 5000 bp, SV40 has been extensively studied as a model for understanding mechanism viral oncogenesis rodents.

参考文章(33)
Michele Carbone, Arthur S. Levine, Oncogenes, antioncogenes, and the regulation of cell growth Trends in Endocrinology and Metabolism. ,vol. 1, pp. 248- 253 ,(1990) , 10.1016/1043-2760(90)90005-N
E.M. Southern, Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology. ,vol. 98, pp. 503- 517 ,(1975) , 10.1016/S0022-2836(75)80083-0
Jonathan A Cooper, Peter Whyte, None, RB and the cell cycle: entrance or exit? Cell. ,vol. 58, pp. 1009- 1011 ,(1989) , 10.1016/0092-8674(89)90495-9
Ilan Bikel, Ximena Montano, Mounzer E. Agha, Myles Brown, Melissa McCormack, Jay Boltax, David M. Livingston, SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen Cell. ,vol. 48, pp. 321- 330 ,(1987) , 10.1016/0092-8674(87)90435-1
J. R. Bischoff, P. N. Friedman, D. R. Marshak, C. Prives, D. Beach, Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 87, pp. 4766- 4770 ,(1990) , 10.1073/PNAS.87.12.4766
Robert G. Martin, Valerie Petit Setlow, Carol A.F. Edwards, Devi Vembu, The roles of the simian virus 40 tumor antigens in transformation of Chinese hamster lung cells. Cell. ,vol. 17, pp. 635- 643 ,(1979) , 10.1016/0092-8674(79)90271-X
Arthur S. Levine, Andrew M. Lewis, Michele Carbone, Kathleen Dixon, Betty-Jean Matthews, Characterization of Hamster Tumors Induced by Simian Virus 40 Small t Deletion Mutants as True Histiocytic Lymphomas Cancer Research. ,vol. 49, pp. 1565- 1571 ,(1989)
D P Lane, S Benchimol, p53: oncogene or anti-oncogene? Genes & Development. ,vol. 4, pp. 1- 8 ,(1990) , 10.1101/GAD.4.1.1