Alterations of the PPP1R3 gene in human cancer.
作者： Satoshi Takakura , Aikou Okamoto , Tadao Tanaka , Jun Yokota , Tatsuya Yamada
DOI:
关键词:
摘要: Recently, the PTEN/MMAC1 gene encoding a protein phosphatase (PP) and PPP2R1B regulatory subunit of PP2A have been identified as being genetically altered in several types human cancers, indicating that aberrations intracellular signaling pathways via PPs are involved carcinogenesis. Here we report genetic alterations PPP1R3 located at chromosome 7q31, which encodes 3 PP1, various cancers. Mutations were detected 5 33 (15%) non-small cell lung cancer lines 2 38 (5%) primary cancers also observed derived from small cancer, an ovarian colorectal gastric cancer. widely dispersed coding region gene. Three 11 mutations nonsense mutations, whereas remaining ones missense most caused substitutions evolutionarily conserved amino acids. These findings suggest alteration plays role development could act tumor suppressor
aacrjournals.org参考文章(21)
Hirota Fujiki, Masami Suganuma, Tumor Promotion by Inhibitors of ProteinZ Phosphatases 1 and 2A: The Okadaic Acid Class of Compounds Advances in Cancer Research. ,vol. 61, pp. 143- 194 ,(1993) , 10.1016/S0065-230X(08)60958-6
Takashi Kohno, Mina Takahashi, Ryokuhei Manda, Jun Yokota, Inactivation of thePTEN/MMAC1/TEP1 gene in human lung cancers Genes, Chromosomes and Cancer. ,vol. 22, pp. 152- 156 ,(1998) , 10.1002/(SICI)1098-2264(199806)22:2<152::AID-GCC10>3.0.CO;2-S
Maree C. Faux, John D. Scott, More on target with proteinphosphorylation: conferring specificity by location Trends in Biochemical Sciences. ,vol. 21, pp. 312- 315 ,(1996) , 10.1016/S0968-0004(96)10040-2
Y. H. Chen, L. Hansen, M. X. Chen, C. Bjorbaek, H. Vestergaard, T. Hansen, P. T. Cohen, O. Pedersen, Sequence of the Human Glycogen-Associated Regulatory Subunit of type 1 Protein Phosphatase and Analysis of Its Coding Region and mRNA Level in Muscle From Patients With NIDDM Diabetes. ,vol. 43, pp. 1234- 1241 ,(1994) , 10.2337/DIABETES.43.10.1234
Takumi Kawabe, Anthony J. Muslin, Stanley J. Korsmeyer, HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. Nature. ,vol. 385, pp. 454- 458 ,(1997) , 10.1038/385454A0
Masayuki Shiseki, Takashi Kohno, Jun-ichi Adachi, Tomoko Okazaki, Toshiyuki Otsuka, Hideaki Mizoguchi, Masayuki Noguchi, Setsuo Hirohashi, Jun Yokota, Comparative allelotype of early and advanced stage non-small cell lung carcinomas. Genes, Chromosomes and Cancer. ,vol. 17, pp. 71- 77 ,(1996) , 10.1002/(SICI)1098-2264(199610)17:2<71::AID-GCC1>3.0.CO;2-Y
Steven Siqing Wang, Edward D Esplin, Jia Ling Li, Liying Huang, Adi Gazdar, John Minna, Glen A Evans, Alterations of the PPP2R1B Gene in Human Lung and Colon Cancer Science. ,vol. 282, pp. 284- 287 ,(1998) , 10.1126/SCIENCE.282.5387.284
Jean C. Zenklusen, Lauren A. Weintraub, Eric D. Green, Construction of a High-Resolution Physical Map of the ∼ 1-Mb Region of Human Chromosome 7q31.1-q31.2 Harboring a Putative Tumor Suppressor Gene Neoplasia. ,vol. 1, pp. 16- 22 ,(1999) , 10.1038/SJ.NEO.7900011
Marie‐Pierre Egloff, Deborah F Johnson, Greg Moorhead, Patricia TW Cohen, Philip Cohen, David Barford, Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1 The EMBO Journal. ,vol. 16, pp. 1876- 1887 ,(1997) , 10.1093/EMBOJ/16.8.1876
Yoji Kukita, Tomoko Tahira, Steve S. Sommer, Kenshi Hayashi, SSCP analysis of long DNA fragments in low pH gel. Human Mutation. ,vol. 10, pp. 400- 407 ,(1997) , 10.1002/(SICI)1098-1004(1997)10:5<400::AID-HUMU11>3.0.CO;2-3