Regional grey matter abnormalities in juvenile myoclonic epilepsy: a voxel-based morphometry study.
作者： Ji Hyun Kim , Jun Ki Lee , Seong-Beom Koh , Sang-Ahm Lee , Jong-Min Lee
DOI: 10.1016/J.NEUROIMAGE.2007.06.025
关键词:
摘要: Abstract Visual assessment of structural MRI is, by definition, normal in patients with juvenile myoclonic epilepsy (JME), a major subsyndrome idiopathic generalized (IGE). However, recent quantitative studies have shown abnormalities cortical and thalamic grey matter (GM) JME. Voxel-based morphometry (VBM) is fully automated, unbiased, operator-independent analysis technique that detects regionally specific differences brain tissue composition on voxel-wise comparison between groups subjects. Using VBM, we examined subcortical GM volume (GMV) 25 JME (15 women, mean age = 22.7 ± 5.1 years) age- sex-matched 44 control subjects (27 age = 23.1 ± 4.3 years). We also performed correlation to delineate possible relationship the GMV increases or reductions increasing duration epilepsy. Group showed superior mesiofrontal region bilaterally thalamus (P
elsevier.com
sci-hub.se 参考文章(39)
J. Natsume, N. Bernasconi, F. Andermann, A. Bernasconi, MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy. Neurology. ,vol. 60, pp. 1296- 1300 ,(2003) , 10.1212/01.WNL.0000058764.34968.C2
John S. Duncan, Brain Imaging in Idiopathic Generalized Epilepsies Epilepsia. ,vol. 46, pp. 108- 111 ,(2005) , 10.1111/J.1528-1167.2005.00321.X
I Savic, Y Österman, G Helms, MRS shows syndrome differentiated metabolite changes in human-generalized epilepsies. NeuroImage. ,vol. 21, pp. 163- 172 ,(2004) , 10.1016/J.NEUROIMAGE.2003.08.034
J. Gotman, C. Grova, A. Bagshaw, E. Kobayashi, Y. Aghakhani, F. Dubeau, Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 15236- 15240 ,(2005) , 10.1073/PNAS.0504935102
Renzo Guerrini, Anna Belmonte, Raffaello Canapicchi, Claudia Casalini, Emilio Perucca, Reversible Pseudoatrophy of the Brain and Mental Deterioration Associated with Valproate Treatment Epilepsia. ,vol. 39, pp. 27- 32 ,(1998) , 10.1111/J.1528-1157.1998.TB01270.X
M. C. Prevett, J. S. Duncan, T. Jones, D. R. Fish, D. J. Brooks, Demonstration of thalarnic activation during typical absence seizures using H2 15O and PET Neurology. ,vol. 45, pp. 1396- 1402 ,(1995) , 10.1212/WNL.45.7.1396
Luiz Eduardo Betting, Susana Barreto Mory, Li Min Li, Iscia Lopes-Cendes, Marilisa M. Guerreiro, Carlos A.M. Guerreiro, Fernando Cendes, Voxel-based morphometry in patients with idiopathic generalized epilepsies. NeuroImage. ,vol. 32, pp. 498- 502 ,(2006) , 10.1016/J.NEUROIMAGE.2006.04.174
FG Woermann, SM Sisodiya, SL Free, JS Duncan, Quantitative MRI in patients with idiopathic generalized epilepsy. Evidence of widespread cerebral structural changes. Brain. ,vol. 121, pp. 1661- 1667 ,(1998) , 10.1093/BRAIN/121.9.1661
Marcos Velasco, Francisco Velasco, Ana Luisa Velasco, Miguel Luján, José Vázquez Mercado, Epileptiform EEG activities of the centromedian thalamic nuclei in patients with intractable partial motor, complex partial, and generalized seizures. Epilepsia. ,vol. 30, pp. 295- 306 ,(1989) , 10.1111/J.1528-1157.1989.TB05301.X
K. Opeskin, R. M. Kalnins, G. Halliday, H. Cartwright, S. F. Berkovic, Idiopathic generalized epilepsy Lack of significant microdysgenesis Neurology. ,vol. 55, pp. 1101- 1106 ,(2000) , 10.1212/WNL.55.8.1101