Siderophore-Mediated Iron Acquisition: Target for the Development of Selective Antibiotics Towards Mycobacterium tuberculosis
作者： Raúl E. Juárez-Hernández , Helen Zhu , Marvin J. Miller
DOI: 10.1007/978-3-319-00303-0_5
关键词:
摘要: This chapter reviews recent pertinent literature on the Mycobacterium tuberculosis siderophore mycobactin and its excreted counterpart carboxymycobactin. Emphasis is placed design of antibiotics to specifically interfere with biosynthesis these siderophores use analogs or conjugates achieve inhibition M. tuberculosis. Although discussion focused biological activity potential anti-tuberculosis agents, a brief description synthetic routes for compounds interest given.
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