Insights into the Biosynthesis of Hormaomycin, An Exceptionally Complex Bacterial Signaling Metabolite
作者： Ivonne Höfer , Max Crüsemann , Markus Radzom , Bernadette Geers , Daniel Flachshaar
DOI: 10.1016/J.CHEMBIOL.2010.12.018
关键词:
摘要: Hormaomycin produced by Streptomyces griseoflavus is a structurally highly modified depsipeptide that contains several unique building blocks with cyclopropyl, nitro, and chlorine moieties. Within the genus Streptomyces, it acts as bacterial hormone induces morphological differentiation production of bioactive secondary metabolites. In addition, hormaomycin an extremely potent narrow-spectrum antibiotic. this study, we shed light on biosynthesis combination feeding studies, isolation biosynthetic nonribosomal peptide synthetase (NRPS) gene cluster, in vivo vitro functional analysis enzymes. nonnatural congeners were generated feeding-induced metabolic rerouting. The NRPS numerous repetitive regions suggest evolutionary scenario for unusual hormone, providing new opportunities evolution-inspired engineering novel peptides.
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