Effect of dexmedetomidine combined with lumbar anesthesia on Th1/Th2 in maternal patients and neonates undergoing caesarean section

摘要: The selection of anesthetic method and drugs is utmost importance for patients undergoing caesarean section. application may affect the immune system maternal patient neonate. Therefore, present study aimed to analyze effect dexmedetomidine combined with lumbar anesthesia on type 1 T-helper cells (Th1) Th2 cytokines in mothers their neonates A total 60 females full-term pregnancies an American Society Anesthesiologists grade I or II who received section were selected equally divided a randomized manner into control group receiving epidural combination treated by anesthesia. visual analogue scale (VAS) score, adverse reactions, traction response neonates' Apgar score compared between two groups. levels interleukin-2 (IL-2), tumor necrosis factor-α (TNF-α), IL-4 IL-10 blood detected reverse transcription-quantitative PCR ELISA. results indicated no statistically significant difference VAS scores, reduced response, as well IL-2 TNF-α expression, significantly decreased, while obviously elevated those controls (P<0.05). Furthermore, markedly declined, whereas expression was apparently enhanced from In conclusion, addition reduces reactions promotes conversion Th1 mothers/nonates after