Evaluating clinical trial design: systematic review of randomized vehicle-controlled trials for determining efficacy of benzoyl peroxide topical therapy for acne

摘要: Determined efficacies of benzoyl peroxide may be affected by study design, implementation, and vehicle effects. We sought to elucidate areas that allow improvement in determining accurate treatment rates active responders randomized controlled trials assessing the efficacy topical treat acne. conducted a systematic review vehicle-controlled evaluating for compared response arms versus those arms. Twelve met inclusion criteria with 2818 patients receiving monotherapy 2004 treatment. The average percent reduction total number acne lesions was 44.3 (SD = 9.2) 27.8 21.0) groups, respectively. non-inflammatory 41.5 % 9.4) group 27.0 20.9) group. decrease inflammatory 52.1 10.4) 34.7 22.7) percentage participants achieving success per designated outcomes 28.6 17.3) 15.2 9.5) Patient responses therapies clinical trial biologic effects vehicles, natural disease progression. “No treatment” groups facilitate determination efficacies.