Inducing Dose Sparing with Inactivated Polio Virus Formulated in Adjuvant CAF01

摘要: The development of new low cost inactivated polio virus based vaccines (IPV) is a high priority, and will be required to eradicate polio. In addition, such vaccine constitutes the only realistic in post-eradication era. One way reduce increase immunogenicity by use adjuvants. CAF01 adjuvant has previously been shown safe potent with several antigens, here we show that mice IPV formulated induced increased systemic protective immunity measured binding neutralization antibody titers serum. also influenced kinetics both cellular humoral response against produce faster, as well stronger, response, dominated IgG2a, IgG2b, IgG2c isotypes specific T cells secreting IFN-γ/IL-2. Finally, intestinal priority vaccines, present strategy on simultaneous priming at an intradermal intramuscular site generate immune responses virus. Taken together, IPV-CAF01 formulation promising ability strong