Antibacterial steroid alkaloids from the stem bark of Holarrhena pubescens.
作者： Asima Chakraborty , Adelheid H Brantner
DOI: 10.1016/S0378-8741(99)00119-1
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摘要: Abstract Holarrhena pubescens (syn. H. antidysenterica ) (L.) WALL. stem bark was tested for antibacterial efficacy against Staphylococcus aureus , epidermidis Streptococcus faecalis Bacillus subtilis Escherichia coli and Pseudomonas aeruginosa using the microdilution broth method as well disc diffusion method. The crude methanolic extract active all bacteria. Further chemical fractionation indicated that activity mainly associated with alkaloids. minimum inhibitory concentration (MIC) bactericidal (MBC) were determined extract, total alkaloids neutral fraction results compared reference antibiotics. showed remarkable S. (MIC=95 μg/ml).
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